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To determine genetic diversity by comparing the whole genome sequences of cattle and human Mycobacterium bovis isolates from Baja California. A whole genome sequencing strategy was used to obtain the molecular fingerprints of isolates of M. Spoligotypes were characterized in silico and single nucleotide polymorphism SNP differences between the isolates were evaluated.

A total of 12 M. Two predominant spoligotypes patterns were seen in both cattle and humans: SB and SB When evaluating SNP differences, the human isolates were intimately intertwined with the cattle isolates. All isolates from humans had spoligotype patterns that matched those observed in the cattle isolates, and all human isolates shared common ancestors with cattle in Baja California based on SNP analysis.

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This suggests that most human tuberculosis caused by M. These reinforce the importance of bovine tuberculosis surveillance and control in this region. View PDF Download full issue. Stuber c. Add to Mendeley Share.

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Under a Creative Commons. Abstract Objectives To determine genetic diversity by comparing the whole genome sequences of cattle and human Mycobacterium bovis isolates from Baja California. Methods A whole genome sequencing strategy was used to obtain the molecular fingerprints of isolates of M.

Conclusions All isolates from humans had spoligotype patterns that matched those observed in the cattle isolates, and all human isolates shared common ancestors with cattle in Baja California based on SNP analysis. Keywords Mycobacterium bovis. Recommended articles Citing articles 0.

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